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Charles Spencer, 3rd Earl of Sunderland

Charles Spencer, 3rd Earl of Sunderland (see here),
born 1675,
First Lord of the Treasury 1718-21 (last pre-Prime Minister),
mar 2ndly to Lady Anne Churchill and had issue:

1. Charles Spencer, 3rd Duke of Marlborough, born 1706.

   
   

2. John Spencer, born 1708,
   of Althorp,
   mar Georgina Carteret [descendant of Henry VII, see descent by Leo van de Pas],
   had issue:

   
   

   1. John Spencer, 1st Earl Spencer, born 1734,
      had issue:

      
      

      1. George Spencer, 2nd Earl Spencer, born 1758,
         mar Lavinia Bingham [born 1762, descendant of the 1641 rebel Rory O'Moore],
         had issue:
         1. Frederick Spencer, 4th Earl Spencer.
            He mar 2ndly to Adelaide Seymour.
            She is descendant of Charles II and of James II. See descent by George Larson. See Table 7 in [Moncreiffe, 1982]. See also here and here.
            4th Earl had issue by 2nd wife. Ancestor of Earls Spencer, and of Princess Diana.

         2. Georgiana Spencer,
            mar George Quin and had issue.

         
         

      2. Henrietta Spencer, born 1761,
         mar Frederick Ponsonby, 3rd Earl of Bessborough (see Ponsonby)
         and had issue:
         1. Lady Caroline Lamb (see here), born 1785, literary figure.
            See her descents from Edward III by Ed Mann.